Abstract Search

ea0029p859 | Endocrine tumours and neoplasia | ICEECE2012

1,25-Dihydroxyvitamin D inhibits cell proliferation by promoting cell-cycle arrest in the human adrenocortical cancer cell line nci-h295r

Pilon C. , Urbanet R. , Vettore S. , Sirianni R. , Pezzi V. , Fallo F.

Vitamin D receptor (VDR) and its ligand 1,25-Dihydroxyvitamin D3 (1,25OHD3) play, in general, an inhibitory role on the growth of normal and malignant cells. However, the mechanisms for this anti-proliferative action remain not completely understood. Recently, a 1,25OHD3-mediated effect on hormone production and steroidogenic genes has been reported in the human steroid-secreting adrenocortical cancer cell line NCI-H295R (Lundqvist J et al. 2010). The aim of this study ...

0 shares

ea0029oc9.3 | Endocrine Tumours & Translation | ICEECE2012

The central role of estrogen receptor α in IGF2 dependent adrenocortical carcinoma (ACC) cell proliferation suggests the use of selective estrogen receptor modulators (SERMs) for the treatment of ACC

Sirianni R. , Chimento A. , De Luca A. , Cerquetti L. , Carpinelli G. , Fallo F. , Pilon C. , Arnaldi G. , Stigliano A. , Pezzi V.

Adrenocortical Cancer (ACC) is characterized by an increased production of insulin-like growth factor 2 (IGF2) and by estrogen receptor (ER) α up-regulation. Aim of this study was to define IGF2 and estrogen signaling interactions in ACC, in order to give new indications for a better therapy. To this aim we used H295R cells and human ACC tissues which display common features: IGF2 activation of downstream effector pathways and over-expression of estrogen-related genes inc...

0 shares

Endocrine Abstracts

1,25-Dihydroxyvitamin D inhibits cell proliferation by promoting cell-cycle arrest in the human adrenocortical cancer cell line nci-h295r

The central role of estrogen receptor α in IGF2 dependent adrenocortical carcinoma (ACC) cell proliferation suggests the use of selective estrogen receptor modulators (SERMs) for the treatment of ACC

BiosciAbstracts